Cabenuva (Cabotegravir/Rilpivirine) Usage Side Effects and More

What is Cabenuva? : Cabenuva is a brand-name prescription medication that’s approved by the Food and Drug Administration (FDA) for use in certain adults with HIV. (HIV is a virus that attacks your immune system.) Cabenuva should be used only after your HIV has been successfully treated with other medications, and you have a low or undetectable level of HIV in your blood.

Limitations of use : If you’ve tried other medications to treat your HIV (such as cabotegravir or rilpivirine) but they weren’t safe or effective, you shouldn’t use Cabenuva. Talk with your doctor to learn more.

Drug details: Cabenuva comes as a liquid solution in a single-dose vial. It’s given as an intramuscular injection (an injection into your muscle).

Cabenuva contains two active drug ingredients: cabotegravir and rilpivirine. These ingredients are in two separate injections that you’ll receive once per month. This medication comes in two strengths: 400 milligrams (mg) of cabotegravir/600 mg of rilpivirine and 600 mg of cabotegravir/900 mg of rilpivirine.

Cabotegravir belongs to a group of medications called integrase strand transfer inhibitors. Rilpivirine belongs to a group of drugs called non-nucleoside reverse transcriptase inhibitors.

Cabenuva dosage : The typical Cabenuva dosage your doctor will prescribe is two injections received at the same time, once per month. Before you start using Cabenuva, your doctor will have you take cabotegravir (Vocabria) and rilpivirine (Edurant). These drugs come as tablets that you take by mouth. They’re taken once daily for the first 28 days of treatment. Then you’ll get your first dose of Cabenuva on the last day that you take the Vocabria and Edurant tablets. The following information describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths: Cabenuva comes as a dosing kit that contains one dose of cabotegravir and one dose of rilpivirine. It comes in two strengths:
400 milligrams (mg) of cabotegravir/600 mg of rilpivirine
600 mg of cabotegravir/900 mg of rilpivirine

Dosage for HIV: Cabenuva is given as two injections into the buttock muscles once every month. It may be given as one injection on each side of your buttock muscle, or in some cases, it can be given on the same side. You will get both injections at the same appointment. Your first dose of Cabenuva will be a higher dose of medication. You’ll receive one injection containing 600 mg of cabotegravir and a second injection with 900 mg of rilpivirine. Then after your first dose, you’ll usually get one injection containing 400 mg of cabotegravir and a second injection with 600 mg of rilpivirine per month.

Cabenuva side effects: Cabenuva can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Cabenuva. These lists do not include all possible side effects. For more information about the possible side effects of Cabenuva, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be concerning or bothersome.

Mild side effects
Mild side effects* of Cabenuva can include:
injection-site reactions
fever
fatigue (lack of energy)
headache
muscle pain
nausea
dizziness
rash
insomnia (trouble sleeping)
Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

Serious side effects: Serious side effects from Cabenuva aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Serious side effects and their symptoms can include:
allergic reaction
liver problems
depression, mood changes, or both
post-injection reactions

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